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ea0045oc5.1 | Oral Communications 5- Endocrine | BSPED2016

Effect of KRN23, a fully human anti-FGF23 monoclonal antibody, on rickets in children with X-linked hypophosphatemia (XLH): 40-week interim results from a randomized, open-label phase 2 study

Padidela Raja , van't Hoff William , Hogler Wolfgang , Portale Anthony , Imel Erik , Boot Annemieke , Linglart Agnes , Whyte Michael , Skrinar Alison , San Martin Javier , Carpenter Thomas

In XLH, high circulating FGF23 causes hypophosphatemia, rickets, and short stature. In our Phase 2 study, 52 XLH children (ages 512 years, ≤Tanner 2) were randomized to receive KRN23 subcutaneously biweekly (Q2W) or monthly (Q4W). Serum phosphate (Pi) was measured biweekly. KRN23 dose was titrated (maximum 2 mg/kg) targeting age-appropriate serum Pi concentrations.The first 36 subjects had a mean 6.6 years of standard-of-care treatment before...

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ea0095p59 | Miscellaneous/other 1 | BSPED2023

Results from learner’s feedback on the use of free, globally accessible CME-accredited e-learning modules in paediatric endocrinology and diabetes

Idkowiak Jan , Wijngaard-de Vugt4 Conny van , van der Zwan Yvonne , Abu-Libdeh Abdulsalam , Kalaitzoglou Evangelia , Drop Sten , Boot Annemieke M , Ng Sze May

Introduction: The ESPE e-Learning web portal is a free, globally accessible online tool to enhance learning in Paediatric Endocrinology and Diabetes. Since August 2022, the e-learning content includes 30 accredited hours of ESPE/ISPAD e-learning Continuing Medical Education (CME) courses with ten core modules each in Paediatric Endocrinology, Paediatric Endocrinology in Resource Limited Setting (RLS) and Paediatric Diabetes. The CME modules were created by wor...

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Endocrine Abstracts

Effect of KRN23, a fully human anti-FGF23 monoclonal antibody, on rickets in children with X-linked hypophosphatemia (XLH): 40-week interim results from a randomized, open-label phase 2 study

Results from learner’s feedback on the use of free, globally accessible CME-accredited e-learning modules in paediatric endocrinology and diabetes

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